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Dr. Antje A.T.S. Reinders, PhD

(calling name 'Simone')

Neuroimaging dissociative identity disorder

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Circulum vitae:

Since 1998 Simone Reinders has performed multidisciplinary research in the field of brain imaging. She started in the neuroimaging field at University Medical Centre Groningen performing a PET study in patients who suffer from dissociative identity disorder. She continued with this topic with her PhD in 1999. In addition, she worked on the methodological refinement of PET data-acquisition and data-reconstruction.

From 2001 to 2003 Simone Reinders worked with Prof. Dr. Christian Büchel in Hamburg (Germany) as a full time visiting PhD student to perform a fear perception fMRI study in healthy subjects. She returned to Groningen to finish her PhD and obtained her doctorate with distinction Cum Laude. She remained working as a post-doctorate researcher on several neuroimaging projects at the University Medical Centre in Groningen until she moved to London in the beginning of 2007.

At the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, Simone Reinders holds the status of Lecturer and is working as a postdoctoral researcher in the Department of Psychosis Studies under the supervision of Dr. Paola Dazzan and Prof. Gareth Barker. In this role she is directly responsible for the coordination of data-analysis pipelines of structural and functional data in various projects conducted in the department. She teaches (both individually and in group settings) fMRI design efficiency and new neuroimaging (data acquisition and analysis) methodologies to undergraduates, PhD students and to other staff within the Division of Psychological Medicine. However, her main task assignment is to work closely with a team of researchers at the IoP and other European centres in the acquisition and analysis of a large imaging dataset obtained as part of the Optimization of Treatment and Management of Schizophrenia in Europe (OpTiMiSE) study. This data is acquired using different imaging modalities, including volumetric MRI, Magnetic Resonance Spectroscopy for glutamate, and 18-F-Dopa PET.

Over the years Simone Reinders has developed a specific interest in the methodological aspect of neuroimaging in parallel with a fascination for dissociative identity disorder. On the latter subject she has been awarded a VENI grant, the most prestigious grant for young investigators in the Netherlands. This grant from the NWO (the Netherlands Organization for Scientific Research) allows her to develop her own research line by supporting the continuation of her neuroimaging research in patients with dissociative identity disorder. The grant supports the study entitled "Conscious of the self? Functional neuroimaging of self-awareness in dissociative identity disorder", which takes place in the Netherlands but is an international multi-centre project that takes place at the IoP in London along with BCN-NiC of the University Medical Centre, Groningen (UMCG) and the VU Amsterdam, both in the Netherlands.

The ability to develop and work on two lines of research in different countries testifies to her organizational and management skills, her capability as a team leader, her ability to prioritize work, and her ambitious nature.

Student supervision and Teaching:
PhD: Currently supervising three PhD student as co-promotor: two as daily supervisor; Three PhD students completed their PhDs: one as daily supervisor, all three co-promotor.
MSc: Ten students have completed their MSc under my supervisioni (7 in Groningen and 2 at the IoPPN), where two received a distinction.
BSc: Four student completed their BSc under my supervision.
Lecturing UK: In the MSc Programmes:1) Mental Health Studies' module, and 2) the MSc Neuroimaging Module at the IoP, KCL, UK.
Lecturing NL: In several BSc and MSc courses at the University of Groningen, NL.

Grants and awards obtained:
2012 Open access publication grant of the NWO.
2010 Honorary Fellow International Society for the Study of Trauma and Dissociation (www.isst-d.org).
2009 - present BCN Internationalisation grant: 1) Collaboration University of Zürich, CH. 2) Collaboration Harvard University, USA.
2007 - 2011 NWO VENI grant. Grant number 451-07-009 (2007 - 2012). Stimulation grant for young excellent researchers from the Netherlands Organisation for Scientific Research (www.nwo.nl).
2006 The David Caul Memorial Award (www.isst-d.org) for the best non-published paper in the field of dissociation.
2001 - 2003 BCN Internationalisation grant: Collaboration Hamburg University, DE.
2001 BCN Poster Prize.

Selected publications (peer reviewed):
19) Reinders AATS, Willemsen ATM, Vos HPJ, den Boer JA, Nijenhuis ERS, Veltman DJ, Loewenstein RJ. “Opposite brain emotion-regulation patterns in identity states of dissociative identity disorder: A PET study and neurobiological model. Psychiatry Res. Neuroimaging 2014 Sep 30;223(3):236-43.
18) Schlumpf YR, Reinders AATS, Nijenhuis ERS, Luechinger R, van Osch MJ, Jäncke L. “Dissociative part-dependent resting-state activity in dissociative identity disorder: a controlled FMRI perfusion study.” PLoS One. 2014 Jun 12;9(6):e98795.
17) Marques TR, Taylor H, Chaddock C, Dell'Acqua F, Handley R, Reinders AATS, Mondelli V, Bonaccorso S, DiForti M, Simmons A, David AS, Murray RM, Pariante CM, Kapur S, Dazzan P “White matter integrity as a marker of response to treatment in first-episode psychosis.” Brain. 2014 Jan;137(Pt 1):172-82.
16) Schlumpf YR, Nijenhuis ERS, Chalavi S, Weder EV, Zimmermann E, Lüchinger R, La Marca L, Reinders AATS, Jäncke L. “Dissociative part-dependent biopsychosocial reactions to backward masked angry and neutral faces: An fMRI study of dissociative identity disorder.” Neuroimage Clin. 2013 Jul 12;3:54-64.
15) Lappin J, Chalavi S, Morgan C, Morgan KD, Reinders AATS, Fearon P, Zanelli J, Jones PB, Murray RM, Dazzan P. "Bilateral hippocampal increase following first-episode psychosis is associated with good clinical, functional and cognitive outcomes." Psychol Med. 2014 Apr;44(6):1279-91.
14) Reinders AATS, Willemsen ATM, Vos HPJ, den Boer JA, Nijenhuis ERS. “Fact or factitious? A psycho-biological study of authentic and simulated dissociative identity states.” PLoS One. 2012;7(6):e39279. Open access: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039279.
13) Reinders AATS, Willemsen ATM, Vos HPJ, den Boer JA, Nijenhuis ERS. "Fact or factitious? A psycho-biological study of authentic and simulated dissociative identity states." PLoS One. 2012;7(6):e39279.
12) Chalavi S, Simmons A, Dijkstra H, Barker GJ, Reinders AATS. "Quantitative and qualitative assessment of structural magnetic resonance imaging data in a two-center study." BMC Med Imaging. 2012 Aug 6;12(1):27.
11) Handley R, Zelaya FO, Reinders AATS, Marques TR, Mehta MA, O'Gorman R, Alsop DC, Taylor H, Johnston A, Williams S, McGuire P, Pariante CM, Kapur S, Dazzan P. "Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain." Hum Brain Mapp. 2012.
10) Mourao-Miranda J, Reinders AATS, Rocha-Rego V, Lappin J, Rondina J, Morgan C, Morgan KD, Fearon P, Jones PB, Doody GA, Murray RM, Kapur S, Dazzan P. "Individualized prediction of illness course at the first psychotic episode: a support vector machine MRI study." Psychol Med. 2012;42(5):1037-47.
9) Reinders AATS. `Cross-examining dissociative identity disorder: Neuroimaging and etiology on trial'. In press: Neurocase (Invited review paper).
8) den Boer JA, Reinders AATS, Glas G. "On looking inward; revisiting the role of introspection in neuroscientific and psychiatric research." Theory and Psychology 2008;18(3):380-403.
7) Reinders AATS, Nijenhuis ER, Quak J, Korf J, Haaksma J, Paans AMJ, Willemsen ATM, den Boer JA. "Psychobiological characteristics of dissociative identity disorder: a symptom provocation study." Biol Psychiatry. 2006 Oct 1;60(7):730-40.
6) Reinders AATS, Gläscher J, de Jong JR, Willemsen ATM, den Boer JA, Büchel C. `Detecting fearful and neutral faces: BOLD latency differences in amygdala-hippocampal junction'. NeuroImage. 2006B; 33(2): 805-814.
5) Reinders AATS, den Boer JA, Büchel C. `The robustness of perception'. European Journal of Neuroscience. 2005; 22(2): 524-530.
4) Reinders AATS, Nijenhuis ER, Paans AMJ, Korf J, Willemsen ATM, den Boer JA. One brain, two selves. Neuroimage. 2003;20(4):2119-25.
3) Reinders AATS, Willemsen ATM, Georgiadis JR, Hovius M, Paans AMJ, den Boer JA. Interscan displacement-induced variance in PET activation data is excluded by a scan-specific attenuation correction. Neuroimage. 2002;17(4):1844-53.
2) Boshuisen ML, Ter Horst GJ, Paans AM, Reinders AATS, den Boer JA. "rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest." Biol Psychiatry. 2002;52(2):126-35.
1) Reinders AATS, Paans AMJ, de Jong BM, den Boer JA, Willemsen ATM. "Iterative versus filtered backprojection reconstruction for statistical parametric mapping of PET activation measurements: a comparative case study." Neuroimage. 2002;15(1):175-81.

3) Reinders AATS, Willemsen ATM. “Dissociative Identity Disorder and Fantasy Proneness: A PET Study of Authentic and Enacted Dissociative Identity States”. Chapter 16 in PET and SPECT in Psychiatry (2013): Dierckx RAJO, Otte A, De Vries EFJ, van Waarde A (eds), Den Boer JA (guest editor). Heidelberg-Berlin-New York: Springer Verlag.
2) Reinders AATS, Nijenhuis ERS, Quak J, Korf J, Haaksma J, Paans AMJ, Willemsen ATM, den Boer JA. "The Psychobiology of dissociative identity disorder". In: Reichertz, Jo and Zaboura, Nadia (editors), "Akteur Gehirn - oder das vermeintliche Ende des handelnden Subjekts. Eine Kontroverse". Wiesbaden: VS Verlag 2006 ; 207-226.
1) Reinders AATS. `From methods to meaning in functional neuroimaging'. PhD thesis with distinction Cum Laude.

Last update 25 November 2014 © a.a.t.s.reinders 2008-2014