Neuroimaging-DID

Circulum vitae:

Since 1998 Simone Reinders has performed multidisciplinary research in the field of brain imaging. She started in the neuroimaging field at University Medical Centre Groningen performing a PET study in patients who suffer from dissociative identity disorder. She continued with this topic with her PhD in 1999. In addition, she worked on the methodological refinement of PET data-acquisition and data-reconstruction.

From 2001 to 2003 Simone Reinders worked with Prof. Dr. Christian Büchel in Hamburg (Germany) as a full time visiting PhD student to perform a fear perception fMRI study in healthy subjects. She returned to Groningen to finish her PhD and obtained her doctorate with distinction Cum Laude. She remained working as a post-doctorate researcher on several neuroimaging projects at the University Medical Centre in Groningen until she moved to London in the beginning of 2007.

At the Institute of Psychiatry (IoP), King's College London, Simone Reinders holds the status of Lecturer, working as an image analyst in the Division of Psychological Medicine under the supervision of Dr. Paola Dazzan and Prof. Gareth Barker. In this role she is directly responsible for the coordination of data-analyses pipelines of structural and functional data in various projects conducted in the department. Furthermore, she teaches (both individually and in group settings) fMRI design efficiency and new neuroimaging (data acquisition and analyses) methodologies to undergraduates, PhD students and to other staff within the Division of Psychological Medicine.

Over the years Simone Reinders has developed a specific interest in the methodological aspect of neuroimaging in parallel with a fascination for dissociative identity disorder. On the latter subject she has been awarded a VENI grant, the most prestigious grant for young investigators in the Netherlands. This grant from the NWO (the Netherlands Organization for Scientific Research) allows her to develop her own research line by supporting the continuation of her neuroimaging research in patients with dissociative identity disorder. The grant supports the study entitled "Conscious of the self? Functional neuroimaging of self-awareness in dissociative identity disorder", which takes place in the Netherlands but is an international multi-centre project that takes place at the IoP in London along with BCN-NiC of the University Medical Centre, Groningen (UMCG) and the Amsterdam Medical Centre (AMC), both in the Netherlands.

Grants and awards obtained:
1) A.A.T.S. Reinders was awarded a VENI grant in 2007 (no. 451-07-009) for young excellent researchers from the Netherlands Organisation for Scientific Research (www.nwo.nl).
2) A.A.T.S. Reinders was awarded the David Caul Award in 2006 from the International Society for the Study of Trauma and Dissociation (http://www.isst-d.org/about/awards.htm). The David Caul Memorial Award was given for the best paper in the field of dissociation.

Selected publications:
1) A.A.T.S. Reinders. `Cross-examining dissociative identity disorder: Neuroimaging and etiology on trial'. In press: Neurocase (Invited review paper).
2) A.A.T.S. Reinders, E.R.S. Nijenhuis, J. Quak, J. Korf, J. Haaksma, A.M.J. Paans, A.T.M. Willemsen, J.A. den Boer. `Psycho-biological characteristics of dissociative identity disorder: neural, physiologic, and subjective findings from a symptom provocation study'. Biological Psychiatry. 2006A; 60(7): 730-740.
3) A.A.T.S. Reinders, J. Gläscher, J. R. de Jong, A.T.M. Willemsen, J.A. den Boer, C. Büchel. `Detecting fearful and neutral faces: BOLD latency differences in amygdala-hippocampal junction'. NeuroImage. 2006B; 33(2): 805-814.
4) A.A.T.S. Reinders, J.A. den Boer, C. Büchel. `The robustness of perception'. European Journal of Neuroscience. 2005; 22(2): 524-530.
5) A.A.T.S. Reinders, E.R.S. Nijenhuis, A.M.J. Paans, J. Korf, A.T.M. Willemsen, J.A. den Boer `One brain, two selves'. NeuroImage. 2003; 20(4): 2119-2125. Mentioned in Nature News and others.

Books/chapters:
6) A.A.T.S. Reinders, E.R.S. Nijenhuis, J. Quak, J. Korf, J. Haaksma, A.M.J. Paans, A.T.M. Willemsen, J.A. den Boer. `The Psychobiology of dissociative identity disorder'. In: Reichertz, Jo and Zaboura, Nadia(editors), `Akteur Gehirn - oder das vermeintliche Ende des handelnden Subjekts. Eine Kontroverse'. Wiesbaden: VS Verlag 2006; 207-226.
7) A.A.T.S. Reinders. `From methods to meaning in functional neuroimaging'. PhD thesis with distinction Cum Laude.

Abstracts:
2009
1) A.A.T.Simone Reinders, A.T. Willemsen, M.C. van Ekeren, H.P. Vos, J. Haaksma, J.A. den Boer, E.R. Nijenhuis. “The Dissociative Brain: Feature or ruled by Fantasy?” To be presented at the 15th Annual Meeting of the Organization for Human Brain Mapping, June 18-23, San Francisco, California, U.S.A.
2) Rowena Handley, S. Reinders, T. Marques, C. Pariante, P. McGuire, P. Dazzan. “The Effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study”. To be presented at the 12th ICOSR (International Congress on Schizophrenia Research), March 28 - April 1, San Diego, U.S.A. Schizophrenia Bulletin 2009: 35 (supplement 1), p184
3) Paola Dazzan, K. D. Morgan, S. Reinders, C. Morgan, P. Fearon, J. Zanelli1, J. Suckling, P. B. Jones, P. K. McGuire, R. M. Murray, J. Lappin. “Effects of antipsychotics on brain structure at the first psychotic episode and 6 years later”. To be presented at the 12th ICOSR (International Congress on Schizophrenia Research), March 28 - April 1, San Diego, U.S.A. Schizophrenia Bulletin 2009: 35 (supplement 1), p202
4) Paola Dazzan, K. D. Morgan, C. Morgan, A. S. Reinders, J. Zanelli, K. G. Orr, G. Hutchinson, P. K. McGuire, P. B. Jones, J. Leff, P. Fearon, R. M. Murray, J. Lappin. “Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode”. To be presented at the 12th ICOSR (International Congress on Schizophrenia Research), March 28 - April 1, San Diego, U.S.A. Schizophrenia Bulletin 2009: 35 (supplement 1), p207
5) Julia M. Lappin, K. D. Morgan, A. A. Reinders, C. M. Morgan, J. Suckling, P. Fearon, P. Jones, R. M. Murray, P. K. McGuire, P. Dazzan. “Duration of untreated psychosis predicts poor outcomes but this is not caused by global brain changes”. To be presented at the 12th ICOSR (International Congress on Schizophrenia Research), March 28 - April 1, San Diego, U.S.A. Schizophrenia Bulletin 2009: 35 (supplement 1), p214
2008
6) Simone Reinders, Van Ekeren, M., Vos, H., Haaksma, J., Willemsen, A. T. M., Den Boer, J. A., Nijenhuis, E. R. S. “The dissociative brain: Feature or ruled by fantasy?” Presented at the 25th Conference of the International Society for the Study of Trauma and Dissociation (ISSTD), Chicago, U.S.A., November 15-17. Proceedings of the 25th Conference of the International Society for the Study of Trauma and Dissociation 2008, p64
7) Reinders, A. A. T. S., Van Ekeren, M., Vos, H., Haaksma, J., Willemsen, A. T. M., Den Boer, J. A., Nijenhuis, E. R. S. “The dissociative brain: Feature or ruled by fantasy?” Presented at the First Conference of the European Society of Trauma and Dissociation (ESTD), Amsterdam, April 17-19. Proceedings of the First Conference of the European Society of Trauma and Dissociation 2008, p30
8) Paola Dazzan, Kevin Morgan, A.A.S.T. Reinders, Craig Morgan, Paul Fearon, Jolanta Zanelli, Helen Fisher, Peter Jones, Robin Murray, Philip McGuire, Julia Lappin. “Grey and white matter volume changes 6 years after the onset of psychosis”. Presented at the 1st Schizophrenia International Research Society Conference, June 21-25, Venice. Schizophrenia Research, Volume 102, Issues 1-3, Supplement 2, June 2008, p69
9) Julia Lappin, Kevin Morgan, Simone Reinders, Craig Morgan, Paul Fearon, Jolanta Zanelli, Peter Jones, Robin Murray, Philip McGuire, Paola Dazzan. “Duration of untreated illness and brain structure changes at 6-year follow-up: the effect of gender”. Presented at the 1st Schizophrenia International Research Society Conference, June 21-25, Venice. Schizophrenia Research, Volume 102, Issues 1-3, Supplement 2, June 2008, p76
10) Rowena Handley, Reinders Simone, Marques Tiago, Pariante Carmine, McGuire Philip, Dazzan Paola. “Neural correlates of audio-visual integration: an fMRI study”. Presented at the 1st Schizophrenia International Research Society Conference, June 21-25, Venice. Schizophrenia Research, Volume 102, Issues 1-3, Supplement 2, June 2008, p105
11) R. Burmicz, A. Reinders, P. Dazzan, and A. Simmons. “Cortical thickness measurements as a function of choice of T1-weighted volume”. Presented at the 16th scientific meeting of the International Society for Magnetic Resonance in Medicine 16th scientific meeting, Toronto, Canada, May 3-9
2006
12) Georgiadis JR, S. Reinders, R. Kuipers, A. Nieuwenburg, J. Pruim, R. Kortekaas. “Orgasm in the female brain: a [15O]-H2O PET study”. Presented at: European Association for Nuclear Medicine, Athens, Greece. Poster number: P315. Eur J Nucl Med 2006: 33 (supp 2)
13) Georgiadis JR, S. Reinders, A. Paans, R. Kortekaas. “Brain activation during human male ejaculation revisited”. Presented at: European Association for Nuclear Medicine, Athens, Greece. Oral presentation: Session 306, program number 80. Eur J Nucl Med 2006: 33 (supp 2)
2005
14) A.A.T.S. Reinders, J.A. den Boer, J. Gl ̈ scher, J.R. de Jong, A.T.M. Willemsen, C. a Bchel. “Detecting fearful and neutral faces: BOLD latency differences in amygdala hippocampal junction”. Presented at the 11th Annual Meeting of the Organisation for Human Brain Mapping, June 13-17, Toronto, Ontario, Canada. Neuroimage 2005: 26 (supplement 1), 219 T-AM
15) A.A.T.S. Reinders, E.R.S. Nijenhuis, J. Quak, J. Korf, J. Haaksma, A.M.J. Paans, A.T.M. Willemsen, J.A. den Boer. “Psycho-Biological characteristics of dissociative identity disorder: rCBF, physiologic, and subjective findings from a symptom provocation study”. Presented at the 11 th Annual Meeting of the Organisation for Human Brain Mapping, June 13-17, Toronto, Ontario, Canada. Neuroimage 2005: 26 (supplement 1), 292 T-PM
2004
16) J. Postler, R. de Bleser, C. Kauschke, A.A.T.S. Reinders, C. Weiller, C. Buchel. “The neural processing of naming nouns and verbs with special reference to age-of-acquisition. An event-related fMRI study”. Presented at: The international conference ““The Science of Aphasia”” (SoA) 2004, Potsdam, Sept 16-21. ̈ 17) A.A.T.S. Reinders, J.A. Den Boer, C. Buchel. “Perceiving emotional and neutral images appearing from dynamically decreasing random visual noise”. Presented at the 10th Annual Meeting of the Organisation for Human Brain Mapping, June 13- 17, Budapest, Hungary. NeuroImage 2004: 22 (supplement 1), S6 (MO 220)
18) J.R. Georgiadis, R. Kuipers, A. Nieuwenburg, A.A.T.S. Reinders, J. Pruim, A. van Roon, G. Holstege. “Female sexual orgasm: A PET study”. Presented at the 10th Annual Meeting of the Organisation for Human Brain Mapping, June 13-17, Budapest, Hungary. NeuroImage 2004: 22 (supplement 1), S5 (MO 182)
2003
19) A.A.T.S. Reinders, J.A. Den Boer, C. Weiller, C. Buchel. “The time-course of perception for emotional and neutral images appearing in visual noise: An event-related fMRI study”. 76. Kongress Deutsche Gesellschaft f ̈ Neurologie mit fortbildungsakademie, September 3 - 6, 2003. Aktuelle Neurologie 2003: 30 (supplement), S7 and Oral Presentation
2002
20) A.A.T.S. Reinders, A.T.M. Willemsen, J.R. Georgiadis, M. Hovius, A.M.J. Paans, J.A. den Boer. “Motion related variance in PET activation data is excluded by a scan specific calculated attenuation correction”. Presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2-6, 2002, Sendai, Japan. Available on CD-Rom in NeuroImage 2002: Vol. 16, No.2
21) J.R. Georgiadis, A.A.T. Reinders, A.M.J. Paans, L.C. Meiners, F.H.C. van der Graaf, G. Holstege. “Brain control of human sexual behaviour: male ejaculation”. Society for Neuroscience, 32nd Annual Meeting in Orlando, November 2 - 7, 2002 (Online Program No. 681.13)
2001
22) A.A.T.S. Reinders, A.M.J. Paans, B.M. de Jong, J.A. den Boer, A.T.M. Willemsen. “Iterative versus filtered backprojection reconstruction for statistical parametric mapping of PET activation measurements: a comparative study”. Presented at the 48th Annual Meeting of the Society of Nuclear Medicine, June 23-27, Toronto, Ontario, Canada
23) A.A.T.S.Reinders, J.Quak, E.R.S. Nijenhuis, H.P.J.Vos, A.M.J.Paans, A.T.M.Willemsen, J.Korf, J.A. den Boer. “Identity state-dependent processing of neutral and traumatic scripts in Dissociative Identity Disorder as assessed by PET (Positron Emission Tomography)”. Presented at the 7th Annual Meeting of the Organisation for Human Brain Mapping, June 10-14, Brighton, UK. NeuroImage 2001: 13 (supplement), S1093
24) A.A.T.S.Reinders, J.Quak, E.R.Nijenhuis, J.Korf, J.A.den Boer. “Processing of neutral and traumatic scripts in DID, assessed by PET”. The World Journal of Biological Psychiatry 2001:2 (Suppl. 1), 150S (0041-06)
25) M.L.Boshuisen, A.A.T.S.Reinders, A.M.J.Paans, J.A.den Boer. “rCBF in panic disorder patients and controls in rest and during a pentagastrin-induced panic attack”. Presented at the 7th Annual Meeting of the Organisation for Human Brain Map- ping, June 10-14, Brighton, UK. NeuroImage 2001: 13 (supplement), S385
26) M.L.Boshuisen, A.A.T.S.Reinders, A.M.J.Paans, J.A.den Boer. “Changes in rCBF of panic disorder patients due to effective treatment with sertraline”. Presented at the 7th Annual Meeting of the Organisation for Human Brain Mapping, June 10-14, Brighton, UK. NeuroImage 2001: 13 (supplement), S1030
27) M.L.Boshuisen, A.A.Reinders, A.M.Paans, J.A.den Boer. “rCBF and panic: Panic disorder patients and controls compared”. The World of Biological Psychiatry 2001:2 (supplement 1), 87S (0021-01)
28) M.L.Boshuisen, A.A.Reinders, A.M.Paans, J.A.den Boer. “Changes in rCBF due to affective treatment with sertraline”. The World of Biological Psychiatry 2001:2 (supplement 1), 88S (0021-08)

Dr. A.A.T.Simone Reinders, Msc PhD